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Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage
Sponsor: National Taiwan University Hospital
Summary
This trial is a phase IIa human clinical study, in which 60 patients with intracerebral hemorrhage (ICH) at basal ganglion or thalamus within 6 h after onset will be enrolled. Patients will be randomly assigned as treatment group or control group as 1:1 distribution. Early initiation of celecoxib within 6 h after ICH and treatment for 21 days will be performed. The safety will be evaluated by drug adverse effects. The efficacy will be assessed by hematoma expansion, brain edema, and 3-month modified Rankin scale.
Key Details
Gender
All
Age Range
20 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-01-01
Completion Date
2027-12-31
Last Updated
2024-09-20
Healthy Volunteers
No
Conditions
Interventions
Celecoxib 200mg
Using celecoxib (200 mg/day) for 21 days starting within 6 hours after onset of ICH
Locations (1)
Natinal Taiwan University Hospital
Taipei, Taiwan