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Modulating Exercise Dosage to Improve Concussion Recovery
Sponsor: University of Colorado, Denver
Summary
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.
Official title: Modulating Exercise Dosage to Improve Concussion Recovery: a Randomized Clinical Trial
Key Details
Gender
All
Age Range
13 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
216
Start Date
2022-08-05
Completion Date
2027-02-01
Last Updated
2024-09-26
Healthy Volunteers
No
Interventions
High Dose Exercise
The investigators will initially test and randomize adolescents ages 13-18 years old ≤14 days post-concussion to high dose aerobic exercise (\>150 min/week, individualized intensity level) or standard-of-care (symptom limited, self-guided physical activity), and re-test upon symptom resolution and 8-weeks post symptom resolution
Locations (3)
University of Colorado Denver
Aurora, Colorado, United States
Boston Children's Hospital
Boston, Massachusetts, United States
Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, United States