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Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
Sponsor: Erika Forbes
Summary
The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.
Key Details
Gender
All
Age Range
18 Years - 26 Years
Study Type
INTERVENTIONAL
Enrollment
21
Start Date
2022-06-17
Completion Date
2025-11-30
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
Theta Burst Stimulation
TBS, a next-gen form of transcranial magnetic stimulation (TMS), requires shorter duration and frequency of stimulation and provides comparable clinical efficacy to traditional repetitive TMS for depression. Thus it is an appropriate technique for use with young adults with depression. TBS can be delivered safely and effectively on an accelerated schedule with two sessions/day. Based on an earlier (ongoing) study of TBS to dorsomedial prefrontal cortex, investigators will administer TBS to dmPFC over 2 weeks in young adults with depression. Addressing the behavioral aspects of anhedonia and reward processing, a subset of participants will also receive positive affect training. Magnetic resonance imaging will guide the personalized location of TBS and will be used to examine change in frontostriatal circuitry with TBS. This study has the potential to influence development of new treatments for depression and anhedonia, with possible mechanisms in frontostriatal brain function.
Locations (1)
The University of Pittsburgh, Department of Psychiatry
Pittsburgh, Pennsylvania, United States