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Acute Recording of Stereotyped High-Frequency Oscillations
Sponsor: Mayo Clinic
Summary
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.
Official title: Acute Recording of Stereotyped High-Frequency Oscillations With a Closed-Loop Brain Interchange System in Drug-Resistant Epilepsy
Key Details
Gender
All
Age Range
3 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2021-09-01
Completion Date
2027-03-31
Last Updated
2026-03-23
Healthy Volunteers
No
Conditions
Interventions
Brain Interchange System
The CorTec Brain Interchange (BIC) is an implantable system with sensing and stimulation capability dedicated to promoting brain computer interface and closed-loop neuromodulation research. It is an externally powered implant which can provide neural data to a nearby computing station (communication unit connected to a personal computer) continuously. In return, computing station controls the implant e.g. for generating therapeutic electrical stimulation to the brain. It is expected that BIC will catalyze translational applications of electroceuticals in human subject by making the neural data immediately available as well as permit the investigation of novel closed-loop neuromodulation applications.
Locations (2)
Mayo Clinic
Rochester, Minnesota, United States
Baylor College of Medicine
Houston, Texas, United States