Clinical Research Directory

Inclusion Criteria: * Patients who are aged ≥ 18 years. * Patients who have histologically confirmed metastatic or unresectable GIST. * Patients who received imatinib at a fixed dose or 1 other TKI as prior treatment regimens. Patients who experienced intolerance to prior therapies must have objective disease progression before enrollment. * Patients must have at least a measurable lesion according to mRECIST Version 1.1. * According to the current GIST national guidelines, patients who receive second-line treatments, including but not limited to sunitinib, imatinib dose escalation, ripretinib, dasatinib, and other drug treatments. * Patients with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 to 2 at screening. Exclusion Criteria: * Patients who previously received two or more TKIs as prior treatment regimens. * Patients with a life expectancy of fewer than three months. * Patients who are pregnant and lactating. * Patients with an estimated poor adherence or inability to complete follow-up. * Patients who are not appropriate to enroll due to the investigator's consideration.