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Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans
Sponsor: University of Calgary
Summary
1. to investigate the association between route of administration of exogenous estrogen (transdermal vs. oral) and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not aligning with sex at birth) women. 2. to investigate the association between exogenous testosterone exposure and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not aligning with sex at birth) men.
Official title: Hormone Therapy and Angiotensin-Dependent Arterial and Renal
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2020-11-30
Completion Date
2025-11-30
Last Updated
2025-03-27
Healthy Volunteers
Yes
Conditions
Interventions
Captopril Tablets
Captorpril challenge to each participant
Iohexol
Iohexol infusion to evaluate measured GFR
Locations (1)
University of Calgary
Calgary, Alberta, Canada