Clinical Research Directory

Inclusion Criteria: 1. Newly diagnosed patients with primary colorectal cancer confirmed by histopathology (no restriction on histological type); 2. Patients diagnosed as stage I-III and feasible for radical bowel surgery; 3. Patients diagnosed by stage IV (only colorectal cancer patients with liver metastasis at the time of diagnosis) and feasible radical bowel resection or complete resection of liver metastasis; 4. No gender limitation, age ≥18; 5. ECOG score ≤1; 6. Life expectancy ≥5 years; 7. Those who fully understand the study and voluntarily sign the informed consent. Exclusion Criteria: 1. Blood transfusion was performed during surgery or 2 weeks before surgery; 2. complicated with primary malignant tumors of other organs; 3. With colonic obstruction, intestinal perforation and other symptoms requiring emergency treatment; 4. Colorectal cancer was diagnosed with extrahepatic metastasis; 5. Neoadjuvant therapy (such as radiotherapy and chemotherapy) before radical bowel resection; 6. Radical bowel resection was performed after endoscopic surgery; 7. Concomitant symptoms and/or family history collection suggest hereditary colorectal cancer; 8. serious mental illness or drug abuse; 9. patients with serious heart, lung and vascular diseases who cannot tolerate surgery; 10. pregnant or lactating women; 11. Participate in other interventional clinical investigators within 3 months 12. Poor compliance, unable to complete the study according to the judgment of the researcher.