Clinical Research Directory

Inclusion Criteria: 1. Voluntarily participate in clinical research, fully understand and inform this research and sign the Informed Consent Form (ICF), and are willing to follow and have the ability to complete all experimental procedures; 2. The age when signing the informed consent form is 18 to 65 years old, male or female; 3. Advanced gastric adenocarcinoma patients diagnosed with clinical stage II-III by CT, MRI, gastroscope and pathology (based on the 8th edition UICC/AJCC staging); 4. The function of major organs is normal; 5. No history of gastric cancer surgery, chemotherapy or immunotherapy; 6. Not accompanied by systemic infection requiring antibiotic treatment; 7. After general examination, it is planned to undergo neoadjuvant immunotherapy and neoadjuvant chemotherapy followed by surgery; 8. No contraindications related to CT and MRI examinations; 9. ECOG score of 0-2 points; Exclusion Criteria: 1. The patient has a history of chemotherapy and immunotherapy in the past; 2. The patient cannot undergo CT or MRI scan, or has artifacts that cannot be assessed; 3. The patient refuses to participate in the study; 4. Patients who are going to undergo or have previously received organ or bone marrow transplantation; 5. The patient is pregnant, breastfeeding or unable to take appropriate contraceptive measures; 6. Patients with mental illness or related medical history, such as: the patient cannot understand the relevant requirements of this study; 7. Patients with human immunodeficiency virus (HIV) infection, active pulmonary tuberculosis or other severe, acute and chronic diseases that may increase the risk of participating in research and research drugs, and who are judged by the investigator to be unsuitable for participating in clinical research; 8. Other relevant factors are considered unsuitable for participating in the research by the researcher.