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RECRUITING
NCT05446584
PHASE2

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Sponsor: University of Texas Southwestern Medical Center

View on ClinicalTrials.gov

Summary

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Key Details

Gender

All

Age Range

55 Years - Any

Study Type

INTERVENTIONAL

Enrollment

75

Start Date

2023-04-20

Completion Date

2027-05-31

Last Updated

2025-05-04

Healthy Volunteers

No

Interventions

DEVICE

High Definition Transcranial Direct Current Stimulation

HD-tDCS for this study is not intended to be a treatment, and will be applied continuously for 30 minutes at sham (0 mA) or 2 mA for active conditions across 3 consecutive daily sessions to probe neural circuit integrity. This specific HD-tDCS device is completely computer driven, running on a laptop using specialized software. Circular electrodes (12-mm in diameter) filled with conductive gel will be placed in a 4x1 ring configuration with the central electrode being the anode surrounded by four cathodes.

Locations (1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States