Inclusion Criteria:
* Newly diagnosed breast cancer.
* 18-75 Years, female.
* Early or locally advanced, histologically documented TNBC (absence of HER2, ER, and PR expression).
* Tumor stage: II-III.
* ECOG Performance Status of 0-1.
* life expectancy is not less than 3 months.
* at least one measurable lesion according to RECIST 1.1.
* Adequate hematologic and organ function.
* Must be willing to use an adequate method of contraception for the course of the study.
Exclusion Criteria:
* Stage Ⅳ (metastatic) breast cancer or bilateral breast cancer.
* Inflammatory breast cancer.
* Has received prior any anti-tumor therapy within the past 12 months prior to signing informed consent, including chemotherapy, targeted therapy, radiation therapy, immunotherapy, biotherapy and TAE.
* Has received prior therapy with an anti-programmed cell death protein 1 (anti-PD-1), anti-programmed death-ligand 1 (anti-PD-L1), or anti-PD-L2 agent or with an agent directed to another co-inhibitory T-cell receptor (e.g., cytotoxic T-lymphocyte-associated antigen-4 \[CTLA-4\], and/or anti-VEGFR agent.
* Has a history of invasive malignancy ≤5 years prior to signing informed consent except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer.
* Major surgical procedure within 4 weeks prior to initiation of study treatment.
* Has a history of autoimmune disease.
* Has a history of hypertension that not well controlled by antihypertensive treatment
* Has a history of myocardial infarction, severe/unstable angina pectoris, NYHA Class 2 or above cardiac insufficiency, clinically significant supraventricular or ventricular arrhythmia, or symptomatic congestive heart failure within the last 6 months.
* Has a history of (non-infectious) pneumonitis, interstitial lung disease or uncontrollable systematicness diseases.
* Administration of a live attenuated vaccine within 28 days prior to initiation of study treatment or anticipation of need for such a vaccine during the study.
* Has a known history of Human Immunodeficiency Virus (HIV).
* Has known active Hepatitis B, Hepatitis C or Autoimmune hepatitis.
* Severe infections within 4 weeks prior to initiation of study treatment, including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia.
* Has active infection (CTCAE≥2) needed the treatment of antibiotic within 2 weeks prior to initiation of study treatment.
* Has evidence of active tuberculosis within 1 year prior to initiation of study treatment.
* Prior allogeneic stem cell or solid organ transplantation.
* Peripheral neuropathy grade ≥2.
* Has clinically significant intestinal obstruction.
* Arterial/venous thrombosis events that occurred within 3 months before enrollment, such as cerebrovascular accidents, deep vein thrombosis, or pulmonary embolism.
* Has hemoptysis symptoms within 2 months before enrollment and the maximum daily hemoptysis ≥ 2.5 ml.
* Clinically significant bleeding symptoms or clear bleeding tendency occurred within 3 months before enrollment.
* Has known genetic or acquired bleeding or thrombotic tendency.
* Abnormal coagulation (INR\>1.5 or APTT\>1.5 x ULN) with bleeding tendency, receiving thrombolysis or anticoagulation therapy, or requiring long-term antiplatelet therapy.
* Has a known hypersensitivity to the components of the study treatment or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins.
* Female patients during pregnancy and lactation, fertile women with positive baseline pregnancy tests or women of childbearing age who are unwilling to take effective contraceptive measures throughout the trial.
* History of neurological or psychiatric disorders, including epilepsy or dementia.
* Any other situation evaluated by researchers.
