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A Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis
Sponsor: Huazhong University of Science and Technology
Summary
Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy. The purpose of this study is to: * Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis. * Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy. * Construct a predictive model for radiation pneumonitis. * Evaluate survival and treatment outcome of patients with radiation pneumonitis.
Official title: A Multicenter Prospective Observational Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2021-02-25
Completion Date
2026-09-01
Last Updated
2022-10-06
Healthy Volunteers
No
Conditions
Interventions
Blood Samples for Biomarkers
blood sample to be taken at baseline, during radiotherapy, and after radiotherapy
Locations (3)
Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Jingjiang People' Hospital
Jingjiang, Jiangsu, China