Clinical Research Directory

Inclusion Criteria: 1. Subjects aged 50-90 year 2. Subjects meet Petersen's criteria for mild cognitive impairment (Petersen, Smith et al. 1999) 3. The CDR of MCI patients can be 0-0.5 4. Amyloid PET should ever be performed Exclusion Criteria: 1. Any subject has a definite diagnosis of epilepsy or history of seizure attack. 2. Current or past history of clinically significant neurological insults affecting brain structure or function like completed stroke, head injury or brain tumor. 3. Any subject has clinically significant or unstable medical diseases including metabolic, renal,liver, lung or cardiovascular disorders including metabolic, renal, liver, lung or cardiovascular disorders. 4. Any subject has current alcohol or other substances abuse and/ or dependence within the recent one year, or prolonged history of major psychiatric disorder like schizophrenia,bipolar disorder, and previously prolonged substances abuse. 5. Any females who is pregnant or lactating. 6. General MRI, TMS and/or PET exclusion criteria including subjects who had received brain aneurysm surgery, or implanted pacemaker, mechanical valves, cochlear implant or other metal devices/ objects that are not MR compatible in the body. Withdrawal criteria 1. Complications onset after intervention that affect efficacy and safety judgments. 2. New onset or progression of disease that may affect outcomes. 3. Use of other therapies or drugs during the intervention period to change cognitive functions. 4. Any subjects who are recognized as high risk of adverse effects by principle investigator.