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RECRUITING
NCT05450978

Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding

Sponsor: University of Pittsburgh

View on ClinicalTrials.gov

Summary

This project focuses on anti-seizure medication (ASM) clearance and physiological factors determining blood concentrations in pregnant adult women with epilepsy and amounts of exposure to their unborn children and nursing infants.

Official title: Physiological-based Pharmacokinetics Approach to Determine the Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding

Key Details

Gender

FEMALE

Age Range

18 Years - 45 Years

Study Type

OBSERVATIONAL

Enrollment

60

Start Date

2022-07-20

Completion Date

2028-04-01

Last Updated

2025-04-18

Healthy Volunteers

No

Interventions

DRUG

Lamotrigine

Anti-seizure concentrations

DRUG

Levetiracetam

Anti-seizure concentrations

DRUG

Oxcarbazepine

Anti-seizure concentrations

Locations (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States