Clinical Research Directory

Inclusion Criteria: 1. Pectus excavatum defect 2. Patient aged ≥18 and \<55 years (patients 55 years and over may still be eligible pending assessment by investigating team and documentation of rationale) 3. Patient willing and able to comply with the study requirements. 4. Patient is eligible to undergo MRI (i.e., no implanted incompatible metal or metal devices, no history of severe claustrophobia). 5. Patient capable of providing valid informed consent. Exclusion Criteria: 1. Patient with a known history of immunodeficiency including HIV, concomitant systemic corticosteroid therapy, chemotherapy, synchronous haematological malignancy or other cause for secondary/primary immunodeficiency. 2. Patient with known severe concurrent or inter-current illness including cardiovascular, respiratory or immunological illness, psychiatric disorders, alcohol or chemical dependence, possible allergies that would, in the opinion of the Principal Investigator, compromise their safety or compliance or interfere with interpretation of study results. 3. Patient with unstable cardiac or respiratory function due to pectus excavatum or those requiring functional repair. 4. Patients with Body Mass Index (BMI) below 18.5 kg/m2 and above 30 kg/m2. NB: Patients with BMI up to 10% higher than the upper limit (up to 33 kg/m2) can be still enrolled if the treating surgeon confirms that BMI is not associated with any kind of pathology. 5. Patient with polycaprolactone (PCL) allergy 6. Women who are currently pregnant or breast feeding, or who are planning to become pregnant within two years after the pectus excavatum camouflage surgery. 7. Women of childbearing potential without an appropriate contraceptive method. 8. Patient with life expectancy \< 36 months.