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Providing Oxygen During Intubation in the NICU Trial
Sponsor: University of Pennsylvania
Summary
Tracheal intubation in the NICU is frequently complicated by severe oxygen desaturation. Apneic oxygenation, a method of applying free flowing oxygen via nasal cannula to apneic patients undergoing intubation, prevents or delays oxygen desaturation during intubation in adults and older children. We propose to enroll patients at two sites (Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia) in a randomized trial in infants undergoing intubation in the NICU to determine if apneic oxygenation, compared with no respiratory support or oxygen during laryngoscopy and intubation attempts (standard care), reduces the magnitude of oxygen desaturation during tracheal intubation encounters.
Official title: Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU
Key Details
Gender
All
Age Range
0 Days - 365 Days
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2022-07-20
Completion Date
2027-02-28
Last Updated
2025-06-18
Healthy Volunteers
No
Interventions
Apneic Oxygenation
Nasal cannula at a rate of 6L/min with 100% FiO2 during laryngoscopy and intubation attempt(s)
Standard of Care
No respiratory support during laryngoscopy and intubation attempt(s) (current standard of care)
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States