Clinical Research Directory

Inclusion Criteria: * Patients is ≥ 18 years of age. * Patients with calcified coronary artery disease requiring percutaneous revascularization with stent implantation who require an IVL with the Shockwave catheter. * Presence of single or multiple calcifications at the lesion site defined by, a) angiography, with fluoroscopic radio-opacities noted without cardiac motion prior to contrast injection involving both sides of the arterial wall in at least one location and total length of calcium of at least 15 mm and extending partially into the target lesion, OR by b) IVUS or OCT, with presence of ≥270 degrees of calcium on at least 1 cross section * Ability to tolerate dual antiplatelet agent (i.e. aspirin, clopidogrel, prasugrel, or ticagrelor for 1 year and single antiplatelet therapy for life) * Ability to give written informed consent. * Patient is able and willing to comply with all follow-up assessments Exclusion Criteria: * Refusal to participate in this study. * Calcific lesion within a \> 4 mm reference segment of the vessel * Lesions in LIMA(left internal mammary artery)/RIMA (rightinternal mammary artery) or at the distal anastomosis of an SVG (saphenous vein grafts) * All the usual relative contraindications to coronary angioplasty according to the clinical practice: * Patient has active systemic infection * Patient has a known untreated coagulation disorder * Patient has allergy to imaging contrast media for which he/she cannot be pre-medicated * Patient is pregnant or nursing * Patients whose life expectancy is \< 1 year * Patients due to move abroad within 1 year