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RECRUITING
NCT05457049

Adjuvant Therapy Omission for Resected NSCLC Patients With Longitudinal Undetectable MRD

Sponsor: Guangdong Association of Clinical Trials

View on ClinicalTrials.gov

Summary

Molecular residual disease (MRD) has strong relationship with clinical outcome in multiple solid tumors. Here, the investigators try to verify the negative predictive value of undetectable MRD, which is considered as a superior prognostic factor for resected NSCLC patients, and not requiring excessive adjuvant therapy. Stage IB-IIIA resected NSCLC patients with landmark and longitudinal undetectable MRD are enrolled and under close surveillance in this study.

Official title: Dynamic Observational Strategy for Stage IB-IIIA Non-Small Cell Lung Cancer Patients After Complete Resection Based on Longitudinal Undetectable Molecular Residual Disease: Prospective, Multicenter, Single-Arm Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

180

Start Date

2022-08-01

Completion Date

2026-12-31

Last Updated

2026-09-16

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

Molecular residual disease test

OncoMRD Lung

Locations (5)

The First People's Hospital of Foshan

Foshan, Guangdong, China

Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences

Guangzhou, Guangdong, China

Shantou Centeral Hospital

Shantou, Guangdong, China

the First Affiliated Hospital of Shantou University Medical College

Shantou, Guangdong, China

Zhongshan City People's Hospital

Zhongshan, Guangdong, China