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Effect of Insect-derived Protein Supplements on Protein Synthesis and mTORC1 Activation
Sponsor: University of California, Davis
Summary
The purpose of this study is to determine the ability of insect-derived protein supplements (IPC80 and Whole Buffalo Powder Ynsect®) to activate the mTORC1 pathway and protein synthesis in muscle cells. To achieve this aim, participants will consume a supplemental dose (0.25 g/kg body weight) of IPC80,Whole Buffalo Powder or whey protein. Blood samples will be drawn before and 15, 30, 60 and 90 minutes after the supplementation. Protein synthesis will be assessed using stably transfected C2C12 muscle cells with a plasmid (pcDNA3 luciferase) and to determine the ability of a protein source to activate mTORC1, stably transfected C2C12 muscle cells with a plasmid (pcDNA3-TOP luciferase) where the luciferase mRNA contains a 5'TOP. 5'TOP which is specifically regulated by mTORC1 activity will be used.
Official title: The Ability of Insect-derived Protein Supplements (IPC80 and Whole Buffalo Powder, Ynsect®) to Activate mTORC1 and Protein Synthesis in Muscle
Key Details
Gender
All
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2022-10-01
Completion Date
2024-09-30
Last Updated
2026-05-08
Healthy Volunteers
Yes
Conditions
Interventions
Whey protein
The participant will consume a supplemental dose of whey protein (0.25 g/kg body weight)
IPC80
The participant will consume a supplemental dose of IPC80 (0.25 g/kg body weight)
Whole Buffalo Powder
The participant will consume a supplemental dose of Whole Buffalo Powder (0.25 g/kg body weight)
Locations (1)
Hickey Laboratory
Davis, California, United States