Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years; * At risk of cardiovascular disease (defined as "Framingham Score" predicted 10-year risk of cardiovascular disease ≥ 20%); * Moderate//severe periodontitis; Exclusion Criteria: * Cardiovascular diseases at baseline (coronary heart disease, stroke and peripheral artery disease); * Received periodontal treatment within the past 6 months; * Pregnant or lactating females; * Non residents of Guangzhou and its surrounding cities or expected to leave Guangzhou or its surrounding cities within 1 year; * Malignant tumors or other end-stage diseases with life expectancy less than 1 year; * End-stage renal disease; * Patients with high bleeding risk, high blood pressures or other situations that make them unable to receive interventions; * Refuse to provide informed consent;