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Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures
Sponsor: Duke University
Summary
The purpose of this study is to examine the effect of early, percutaneous, intra-articular saline lavage on the undiluted synovial fluid microenvironment during the acute phase following intra-articular fracture of the human ankle. We hypothesize that early intervention with percutaneous joint lavage in the first 0-48 hours after injury will attenuate the production of pro-inflammatory cytokines, MMP's and cartilage breakdown products compared to non-lavaged control subjects at the time of surgical fixation.
Official title: The Effect of Early Saline Lavage on Synovial Fluid Composition Following Human Intra-Articular Ankle Fracture
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
41
Start Date
2022-07-22
Completion Date
2024-05-07
Last Updated
2026-04-14
Healthy Volunteers
No
Conditions
Interventions
Saline Lavage
Three rounds of 10cc of sterile 0.9% normal saline will be injected into the injured ankle joint and withdrawn from the joint using an anteromedial 16-gauge needle attached to a 10cc syringe.
No intra-articular saline lavage
Subjects in group 2 will not undergo normal saline lavage.
Lidocaine - intra-articular injection
Intra-articular injection of 10cc of 1% lidocaine without epinephrine via the existing anteromedial 16-gauge needle.
Synovial Fluid Aspiration
Aspiration of ankle joint via standard anteromedial approach. Performed using sterile technique using 16-guage needle attached to 10cc syringe.
Locations (1)
Duke University Medical Center
Durham, North Carolina, United States