Clinical Research Directory

Inclusion Criteria: * Female subjects in reproductive age \>18 \<45. * Subjects with diagnosed papillary thyroid carcinoma with various pathological, stage TNM (I-II). * Subjects not treated with 131I. * Serum TSH concentration 0.1-4.9 mU/l. * Willingness to comply with protocol procedures. Exclusion Criteria: * Hypersensitivity to metformin. * Subjects with polycystic ovarian syndrome or other diseases of the ovaries (primary / secondary ovarian failure). * Subjects taking metformin during last week. * Subjects with liver malfunction and abnormal hepatitis marker results (ALT and AST activity \>3ULN. * Subjects with eGFR below 45ml/min/1.73m2. * Subjects with lactic acidosis or having history of metabolic acidosis. * Subjects with serum AMH concentration below lower range norm. * Subjects with history of congestive heart disease NYHA stage III/IV. * Subjects with acute myocardial ischemia (CCS 3-4). * Subjects with history of sepsis or severe infection. * Subject with lung disease (uncontrolled asthma based on GINA 2000 Guidelines and COPD GOLD ≥ 3 stage). * Positive result of pregnancy test or pregnancy planned during the study. * Alcohol or other substance dependent syndromes. * BMI \<18.5 kg/m2. * Accompanying diseases with poor prognosis in the opinion of the researcher. * As per Investigator (or his designee) judgement, subject cannot participate in the study due to reasons (i.e. medical, psychiatric and/or social reason). * Unreliability or lack of cooperation.