Taiwan Associated Genetic and Nongenetic Small Vessel Disease

RECRUITING

NCT05473637

Sponsor: National Taiwan University Hospital

Summary

The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.

Official title: Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

500

Start Date

2019-01-01

Completion Date

2028-12-31

Last Updated

2026-01-20

Healthy Volunteers

Yes

Conditions

Cerebral Small Vessel Diseases Cadasil HTRA1-Related Autosomal Dominant Cerebral Angiopathy COL4A1-Related Brain Small Vessel Disease With Haemorrhage Fabry Disease Magnetic Resonance Imaging Next-generation Sequencing Stroke

Interventions

DIAGNOSTIC_TEST

MRI

Patients will repeat study-protocol MRI at baseline (enrollment) and at least once in 1 year or 2 years follow-up (depends on availability).

Locations (1)

Department of Neurology, National Taiwan University Hospital

Taipei, Taiwan

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