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Reducing Hypotensive Anesthesia Use with TXA During Orthognathic Surgery
Sponsor: University of Alabama at Birmingham
Summary
This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered. DHA has been proven to be effective although it comes with multiple risks related to organ hypoperfusion including kidney injury, stroke, and cardiac ischemia. Therefore, it may be potentially safer for patients to avoid deliberate hypotensive anesthesia if TXA alone adequately controls blood loss and provides adequate surgical site visualization.
Official title: Does Tranexamic Acid Reduce the Need for Deliberate Hypotensive Anesthesia Within Orthognathic Surgery? a Prospective Study
Key Details
Gender
All
Age Range
12 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2022-11-11
Completion Date
2025-12
Last Updated
2024-12-19
Healthy Volunteers
Yes
Interventions
Avoidance of Deliberate Hypotensive Anesthesia
The anesthesia team will be asked to avoid deliberate hypotensive anesthesia and maintain blood pressure closer to the patient's baseline throughout the surgery.
TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION
1g of tranexamic acid will be given intravenously to patient undergoing orthognathic surgery as routinely performed about 5-15 minutes before first surgical incision.
Locations (1)
UAB Hospital-Highlands
Birmingham, Alabama, United States