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Arginine Metabolism in Youth With Type 2 Diabetes
Sponsor: Baylor College of Medicine
Summary
Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.
Official title: Arginine Metabolism in Pediatric Type 2 Diabetes
Key Details
Gender
All
Age Range
12 Years - 20 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-02-06
Completion Date
2027-08-31
Last Updated
2026-01-27
Healthy Volunteers
Yes
Conditions
Interventions
Stable isotope infusion, oral glucose ingestion, intravenous arginine bolus
On separate study days, each participant will have a stable isotope infusion, ingest oral glucose, and be given an intravenous arginine bolus.
Locations (1)
Texas Children's Hospital / Baylor College of Medicine
Houston, Texas, United States