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ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study
Sponsor: Gyroscope Therapeutics Limited
Summary
The purpose of this study is to evaluate the long-term safety of GT005 in participants with Geographic Atrophy (GA) secondary to AMD who have been treated in an antecedent study.
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
225
Start Date
2022-07-12
Completion Date
2028-06-02
Last Updated
2024-03-22
Healthy Volunteers
No
Conditions
Interventions
GT005
GT005 is a gene therapy for GA and is a recombinant adeno-associated viral serotype 2 (AAV2) vector encoding for human complement factor I. GT005 was administered to all participants in an antecedent study prior to enrollment in ORACLE and GT005 is not administered in the ORACLE study.
Locations (32)
Retina Consultants San Diego - Poway
Poway, California, United States
Southwest Retina Research Center
Durango, Colorado, United States
Vitreo Retinal Associates Pa - the Millennium Center Location
Gainesville, Florida, United States
Rand Eye Institute, Inc. (Rei)
Pompano Beach, Florida, United States
Retina Vitreous Associates of Florida
St. Petersburg, Florida, United States
University Retina and Macula Associates, P.C. - Lemont Office
Lemont, Illinois, United States
Midwest Eye Institute Northside
Indianapolis, Indiana, United States
Wolfe Eye Clinic
West Des Moines, Iowa, United States
The Retina Care Center, Llc - Baltimore Location
Baltimore, Maryland, United States
Ophthalmic Consultants of Boston (OCB)
Boston, Massachusetts, United States
Pepose Vision Institute, P.C - Midwest Vision Research Foundation
Chesterfield, Missouri, United States
Sierra Eye Associates
Reno, Nevada, United States
Columbia University Medical Center
New York, New York, United States
Retina Associates of Western New York
Rochester, New York, United States
Cincinnati Eye Institute
Cincinnati, Ohio, United States
Sterling Vision - Oregon Retina, Llp
Eugene, Oregon, United States
Mid Atlantic Retina - Wills Eye Hospital
Philadelphia, Pennsylvania, United States
Retina Consultants of Austin
Austin, Texas, United States
Texas Retina Associates (Tra) - Dallas Main
Dallas, Texas, United States
Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center
Houston, Texas, United States
Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center
Houston, Texas, United States
Retinal Consultants of San Antonio (Rcsa) - Medical Center
San Antonio, Texas, United States
The University of Melbourne - The Centre for Eye Research Australia (CERA)
Melbourne E., Victoria, Australia
CHU Dijon - Hopital Mitterrand
Dijon, France
CHU de Nantes - Hôtel-Dieu
Nantes, France
Universitaetsklinikum Schleswig-Holstein
Lübeck, Germany
Universitaetsklinikum Tuebingen
Tübingen, Germany
Instituto de microcirugía ocular
Barcelona, Spain
Clinica Baviera
Madrid, Spain
Clinica Universidad de Navarra - Pamplona
Pamplona, Spain
The Retina Clinic London
London, United Kingdom
South Tyneside and Sunderland Nhs Foundation Trust - Sunderland Eye Infirmary
Sunderland, United Kingdom