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Mycosis Culture Collection From Dermatological Isolated
Sponsor: University of Rome Tor Vergata
Summary
This pilot, prospective, observational drug study aims to evaluate the efficacy, tolerability and safety of topical and oral antifungals in the treatment of onychomycosis caused by yeasts, dermatophytic moulds and non-dermatophytic moulds as well as correlate the scores in the MALDI-TOF method for the 'identification of genus and species of higher fungi utilizing the comparison between identification in direct optical microscopy, culture examination and optical microscopy and macroscopic and onychoscopic clinical aspects. Furthermore, an optional substudy will evaluate the drug resistance of clinical isolates using molecular or genetic methods.
Official title: Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2022-07-20
Completion Date
2025-12-25
Last Updated
2024-05-08
Healthy Volunteers
Yes
Interventions
Terbinafine Topical Gel
Topical application of terbinafine
Itraconazole 200 mg
systemic itraconazole pulse therapy
Terbinafine 250 mg
systemic terbinafine
Ciclopirox Topical Gel
Topical application of ciclopirox
Amorolfine 50 MG/ML
Topical application of amorolfine
Locations (1)
Tor Vergata Univerisity Hospital
Rome, Italy