Clinical Research Directory

Inclusion Criteria: * CKD patient stage 3a-5 (\<60 ml/min/1.73 m² estimated by CKD-EPI formula) and not on dialysis, * With a good nutritional status (i.e., absence of malnutrition according to albumin, pre-albumine, BMI and no clinical and paraclinical criteria of malnutrition), * Above 1g protein/ kg bw (ideal body weight), * LPD-naïve patient, * Motivated to LPD introduction (ensure during screening phase patient willingness to modify diet habits with counselling accurate follow-up), * Available to attend the visits planned by the protocol and able to complete the data collection documents (diet record and self-administered questionnaires), * Subject affiliated to a health insurance system or is a beneficiary (art. L.1121-11, Code of Public Health, France), * Having given their informed written consent regarding its participation to the protocol. Exclusion Criteria: * Patient for whom dialysis or transplantation is planned/expected within the next 12 months * Known allergic reactions to the ingredients present in FLAVIS products (milk, eggs, soy, nut), * Uncontrolled Diabetes (HbA1C \>8.5%), * Active cancer (including a 5 years remission period), * Psychiatric disorders or inability to follow the protocol, * Evidence of any active infectious or uncontrolled inflammatory diseases, * Inability to provide blood samples (poor venous capital), * Inability to perform correct 24-hours urine collection, * Any change of the chronic medication within 1 month before screening, * Presence of any significant medical finding or significant history such as uncontrolled systemic diseases that may impact the safety, the interpretation of the results and/or the participation of the subject in the study according to the opinion of the investigator, * Patient with an active implanted medical device * Simultaneous participation in another clinical trial or subject still within the exclusion period of a previous clinical trial. * Vulnerable subjects (art. L. 1121-5 à 8 et L. 1122-1-2, Code of Public Health, France) are also excluded from the clinical trial.