Clinical Research Directory

Inclusion Criteria: • Premature newborns of gestational age (GA) 25/0-27/6 weeks, Exclusion Criteria: * Missing written parental consent * Damages to the nasal mucosa * Maxillofacial defects * Major congenital anomalies (including chromosomal aberrations, cyanotic congenital heart defects, syndromes likely affecting long-term outcome, and major congenital malformations requiring surgical correction during newborn period) * Infants who died before 48 hours, infants in whom the clinical decision to withhold intensive care was made, infants who were not considered viable * Infants with edematous hemolytic disease of newborns, non-immune fetal dropsy, * Multifetal Gestations * Participation in another study with ongoing use of an unlicensed investigational product from 28 days before study enrollment until the end of the study