Clinical Research Directory

Inclusion Criteria: （ - ） Males or females with age between 18 and 65 years old; （ - ） Diagnosis of nonalcoholic fatty liver disease; （ - ） Proton density fat fraction measured by magnetic resonance imaging (MRI-PDFF) ≥8%; （ - ） BMI≥24; Patients who understand the objective of the study; voluntarily participate in the study and have signed the informed consent form; and are able and willing to comply with all requirements, including follow up and evaluations. Exclusion Criteria: （ - ） History of excessive alcohol consumption (alcohol consumption equivalent to ethanol \> 30 g/d for males and \> 20 g/d for females); （ - ） End-stage liver disease (e.g. hepatic cirrhosis or hepatic cancer) or other conditions which may lead to fatty liver; （ - ） Unable to cooperate to complete MR examination; （ - ） Subjects who have used any nonsteroidal anti-inflammatory drug or corticosteroid in the past month; （ - ） Patients with iron deficiency or iron deficiency anemia; （ - ） ALT or AST increased to 8 × upper limit of normal (ULN), and bilirubin increased to 2×ULN; （ - ） Patients with coagulation disorder or haemorrhagic diathesis (platelets \<100×109/L); （ - ） Patients with duodenal ulcer, or previous or existing pancreatitis; （ - ） History of liver abscess; （ - ） History of gallstones (symptomatic or presenting of any stone with a diameter greater than 20mm); （ - ） Patients with gastrointestinal hemorrhage or potential hemorrhage; （ - ） Gastrointestinal tract anomalies, such as gastrointestinal tract atresia or any or other conditions that would result in failed placement in the gastrointestinal tract; （ - ） Patients with history of intestinal obstruction or related disease in the past year; （ - ） Drug abusers or patients with uncontrollable psychiatric disorders; （ - ） Patients with any contraindication to endoscopy based on the investigator's judgment; （ - ） Pregnancy or lactating women; （ - ） Patients who are participating in any other drug or medical device clinical study; （ - ） Patients with any other conditions evaluated by the investigators as unsuitable for participating in the trial;