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RECRUITING
NCT05498038
NA

Exercise Reset for Concussion in a Military Environment

Sponsor: State University of New York at Buffalo

View on ClinicalTrials.gov

Summary

Our primary objective is to show that early, personalized aerobic exercise treatment safely improves concussion recovery, speeds RTD, and reduces persistent symptoms in CSM. Our secondary objectives include demonstrating the clinical utility of our March-in-place test and determining fundamental mechanisms for the effect of exercise rehabilitation on concussion recovery. We will conduct a prospective four-year multicenter mechanistic treatment (Phase 3) RCT in CSM of personalized sub-threshold aerobic exercise added to the PRA compared with the PRA alone. Non-concussed, age-matched SM will serve as a healthy control group (HC) for comparing CSM to normal physiology and to control for the effect of time and of aerobic exercise.

Official title: Exercise Reset for Concussion- Modifying the Buffalo Concussion Protocol for Application in a Military Environment

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

168

Start Date

2024-08-07

Completion Date

2026-09-30

Last Updated

2026-01-21

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Aerobic Exercise

Participants are asked to complete at least 20 minutes of aerobic exercise every day, excluding clinic visits.

Locations (2)

Fort Liberty

Fayetteville, North Carolina, United States

Camp LeJeune

Jacksonville, North Carolina, United States