Clinical Research Directory

Inclusion Criteria: 1. Histologically or cytologically confirmed stage III b or IV NSCLC, according to the International Association for the Study of Lung Cancer staging manual in Thoracic Oncology, 8th edition. 2. Documented ALK-positive disease according to FISH , Ventana IHC ,RT-PCR or NGS; 3. Patients must have demonstrated progression during or after ALK-TKI treatment; 4. Eastern cooperative oncology group performance status (ECOG PS) of 0-2, overall survival\>3 months; 5. Patients need radiotherapy or can receive radiotherapy, such as bone metastatic lesions, intrapulmonary lesions, adrenal lesions, etc. 6. Initially general blood tests including complete blood count, biochemistry, electrolytes, and urine biochemistry were performed as a routine screening in order to identify any abnormalities. 7. Male and female patients must agree to abstain or to use two highly effective forms of contraception during the treatment period and for 90 days after the last dose of study medication. Exclusion Criteria: \-