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Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
Sponsor: Chang Gung Memorial Hospital
Summary
A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.
Key Details
Gender
All
Age Range
20 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
130
Start Date
2022-08-25
Completion Date
2026-08-30
Last Updated
2024-07-16
Healthy Volunteers
Not specified
Conditions
Interventions
exercise based cardiac rehabilitation
The types of exercise are treadmill walking/walking-jogging/jogging, ergometer cycling, stair climbing, or elliptical machine training. The training intensity is gradually increased fortnightly to reach the targeted Borg's rate of perceived exertion (RPE) of 12-14. The training duration is 40 minutes, which included 5-10 minutes of warm-up and cool-down exercises. The training frequency is three sessions per week, with 36 sessions concluding a complete course.
Locations (1)
Chang Gung Memorial Hospital Heart Failure Center
Kaohsiung City, Taiwan