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The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Sponsor: Adrian Vella
Summary
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.
Key Details
Gender
All
Age Range
25 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2022-12-15
Completion Date
2026-12-31
Last Updated
2025-06-04
Healthy Volunteers
No
Conditions
Interventions
Caloric Restriction
Subjects will be instructed to consume a diet of 900 kcal daily using meals derived from "Nutritional Guidelines after Bariatric Surgery". Compliance will be monitored by weekly meetings with the dietician using an electronic record of food intake
Hyperglycemic clamp
Hyperglycemic clamp to measure the effect of glucagon on hepatic metabolism
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States