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Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Sponsor: State University of New York at Buffalo
Summary
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
Official title: The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans
Key Details
Gender
All
Age Range
65 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2023-04-04
Completion Date
2027-08-30
Last Updated
2025-08-22
Healthy Volunteers
Yes
Conditions
Interventions
Nicotinamide riboside
Nicotinamide riboside (NR) is a form of vitamin B3, which is found in fruits, vegetables, meat, and milk. NR is converted into nicotinamide adenosine dinucleotide NAD+. Low NAD+ levels have been linked to Alzheimer's disease and sleep disturbances.
Placebo
The placebo pill will contain micro cellulose powder.
Locations (3)
State University of New York at Buffalo
Buffalo, New York, United States
University at Buffalo State University of New York
Buffalo, New York, United States
Buffalo Veteran Affairs Medical Center
Buffalo, New York, United States