Clinical Research Directory

Inclusion Criteria: * Healthy participants * QTcF ≤ 450 msec at Screening and on admission (ie, on Day -1). * Participants of Japanese descent are defined as: First generation (born to 2 Japanese parents and 4 Japanese grandparents). * Participants of Japanese descent must be between 20 and 60 years of age. * BMI within the range 18-32kg/m2 (inclusive) at Screening. Exclusion Criteria: * Current or recurrent disease * Current or relevant history of physical or psychiatric illness. * Any other significant disease or disorder that, in the opinion of the Investigator, may put the participant at risk. * Female participants who are pregnant or breastfeeding. * Major surgery or hospitalization within 90 days prior to dosing on Day1. * History of allergy or hypersensitivity to an oligonucleotide or GalNAc moiety or any excipients of ALXN2030.