Inclusion Criteria:
1. Patients voluntarily joined the study and signed informed consent
2. Age 18\~75 years old, both male and female
3. Advanced NSCLC diagnosed by histology or cytology, or recurrent NSCLC after radical treatment such as surgery, radiotherapy, chemoradiotherapy
4. At least one measurable lesion based on RECIST v1.1 criteria
5. ECOG PS score: 0-1
6. Have a life expectancy of at least 3 months
7. Fertile women must have a negative serum pregnancy test within 3 days before the first dose and must be non-lactating
Exclusion Criteria:
1. Untreated Brain metastases with clinical symptoms; Or accompanied by meningeal metastasis, spinal cord compression，etc.
2. Uncontrolled pleural, pericardial, or abdominal effusion with clinical symptoms
3. Suffering from other malignant tumors in the past 3 years or at the same time
4. Presence of any active or known autoimmune disease
5. Subjects who had been systematically treated with corticosteroids (\>10 mg/ day of prednisone or other equivalent hormone) or other immunosuppressive agents within 2 weeks prior to the first dose (randomization)
6. Any severe or uncontrolled ocular lesions that, in the judgment of the investigator, may increase the subject's safety risk
7. Have clinical symptoms or diseases of the heart that are not well controlled
8. Patients with hypertension who are not well controlled by antihypertensive medication
9. Any bleeding event of grade 2 or more or hemoptysis (volume of hemoptysis ≥2ml in a single episode) occurring within 2 weeks before the first dose (randomization); Clinically significant bleeding symptoms or definite bleeding tendency before the first medication (randomization)
10. Have known history of serious infections within 1 month prior to the first dose(randomization), including but not limited to infectious complications that require hospitalization, bacteremia, and severe pneumonia; use antibiotics within 1 week prior to the first dose(randomization); have any active infections requiring intravenous systemic therapy, or have a fever \> 38.5°C of unknown cause before the first dose(randomization).
11. Have active or prior documented interstitial pneumonia/interstitial lung disease or pneumonitis that requires glucocorticoid treatment (e.g., radiation pneumonitis); Have active pneumonia at present
12. Have active pulmonary tuberculosis.
13. Have known history of human immunodeficiency virus (HIV) seropositive status or acquired immunodeficiency syndrome (AIDS). Have known active hepatitis B or C.
14. Had received lung radiation therapy within 6 months before the first dose (randomization); Had received major surgical treatment (except diagnostic surgery), systemic chemotherapy, immunotherapy, or other investigational drugs within 4 weeks prior to the first medication (randomization); Received palliative radiotherapy within 2 weeks before the first dose (randomization); Oral administration of molecular targeted drugs, less than 5 half-lives before discontinuation of the drug to the first dose (randomization); Failure to recover from toxicity and/or complications of previous interventions to NCI-CTC AE grade≤1
