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COMPLETED
NCT05510973
NA

Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi

Sponsor: Elizabeth Glaser Pediatric AIDS Foundation

View on ClinicalTrials.gov

Summary

This study will evaluate the implementation of an enhanced package of care, CD4 and tuberculosis lipoarabinomannan (TB-LAM) tests and the initiation of patients on TB prophylaxis \[TPT and CPT\], on retention in care and viral suppression ((\<50 copies/ml) at 6 and 12 months after AHD care and treatment enrollment. The study will also assess the change in AHD screening, management and service uptake indicators among PLHIV clients before and after implementation of the QI collaborative implementation (QICI) project, evaluate the acceptability and feasibility of the AHD package of care among patients and HCWs providing related health services, and conduct a cost analysis of implementing the enhanced AHD package of care in a hub-and-spoke implementation of care model.

Official title: Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi: A Mixed Methods Non-randomized Cluster Study

Key Details

Gender

All

Age Range

Any - Any

Study Type

INTERVENTIONAL

Enrollment

700

Start Date

2021-06-01

Completion Date

2024-12-30

Last Updated

2026-09-10

Healthy Volunteers

No

Interventions

OTHER

Enhanced package for AHD care

The enhanced package of AHD care includes CD4 and tuberculosis lipoarabinomannan (TB-LAM) tests and the initiation of patients on TB prophylaxis \[TPT and CPT\], offered through a hub-and-spoke facility system, with continuous quality improvement (QI)

Locations (13)

Mlambe Mission Hospital

Mlambe, Blantyre, Malawi

Chiradzulu District Hospital

Chiradzulu, Chiradzulu, Malawi

Dedza district hospital

Dedza, Dedza, Malawi

Lobi rural hospital

Lobi, Dedza, Malawi

Mua Mission Hospital

Mtakataka, Dedza, Malawi

Kapiri Mission Hospital

Kapiri, Mchinji, Malawi

St Michael's Guilleme Community Hospital

Mchinji, Mchinji, Malawi

Malamulo Mission Hospital

Thyolo, Thyolo, Malawi

Domasi Rural Hospital

Domasi, Zomba, Malawi

Saint Luke's Mission Hospital

Zomba, Zomba, Malawi

Mchinji District Hopsital

Mchinji, Malawi

Ntcheu District Hospital

Ntcheu, Malawi

Sister Theresa Community Hospital

Ntcheu, Malawi