Clinical Research Directory

Inclusion Criteria: * Active duty military personnel within the range of 18-45 years of age without limitations to gender or ethnicity. * Primary vaccinee (receiving smallpox vaccine for the first time) with a force health protection requirement for the smallpox vaccination * Medical screening for immunization completed and potential participant found eligible for immunization (standard of care) Exclusion Criteria: * Known contraindication to replication deficient smallpox vaccination based on FDA-approved package insert for JYNNEOS™ vaccine. * No indication for replication deficient smallpox vaccination based on FDA-approved package insert for JYNNEOS, ACIP or DoD guidelines * Secondary smallpox vaccinee (patients who had previously received any smallpox vaccine). * Age less than 18 years or age greater than 45 years. * Inability to provide informed consent. * Presence of a moderate or severe acute illness with or without a fever * Pregnancy: We will rely on the subject for an assessment of her pregnancy status, based on answers in the routine adult immunization screening questionnaire. (Screening by history is the current standard of care.) * Scheduled deployment, PCS or TDY that would interfere with the respective follow-up visits. (no planned deployment, TDY or PCS for 65 days after enrollment/visit 1).