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Effect of Remimazolam and Propofol on Postoperative Delirium
Sponsor: Inje University
Summary
Remimazolam is an ultra-short acting benzodiazepine agonist which is used widely for general anesthesia and sedation. Remimazolam has several advantages. Remimazolam is rapidly metabolized by tissue esterase that it does not accumulate even after infusion for long periods of time. The presence of reversal agents (flumazenil) is also advantageous. Also, hemodynamic stability compared to propofol gives clinicians preference to use for geriatric anesthesia. However, the study on the effect of remimazolam compared to propofol on postoperative delirium have not been carried out. The purpose of the study is to compare the incidence of postoperative delirium and recovery profile in elderly patients undergoing orthopedic surgery using either remimazolam or propofol.
Official title: Effect of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Hip and Knee Surgery
Key Details
Gender
All
Age Range
65 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
82
Start Date
2022-08-01
Completion Date
2026-09-30
Last Updated
2026-03-27
Healthy Volunteers
Yes
Interventions
Remimazolam (Byfavo)
Remimazolam is continuously infused based on bispectral index (within 40-60).
Propofol
Propofol is continuously infused based on bispectral index (within 40-60).
Locations (1)
Sanggye Paik hospital
Seoul, South Korea