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Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients
Sponsor: University of Virginia
Summary
This will be a randomized, open-label, controlled trial of patients at high risk of developing preeclampsia examining 81 mg/day vs 162mg/day daily acetylsalicylic acid (ASA) use. Based on screening results, patients will be randomized as outlined below into one of four groups. The proposed study is a pilot to determine if the higher dose of ASA has positive impacts on measures that predict preeclampsia, compared to the lower dose. If positive findings, data from this study could be used to develop a larger trial powered to determine if the higher ASA dose can improve clinical outcomes.
Official title: Low Dose Aspirin for Preterm Preeclampsia Prevention - a Randomized Trial of 81 Vs 162 Mg/day Dose in High-risk Patients
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2022-10-01
Completion Date
2025-12-31
Last Updated
2025-01-15
Healthy Volunteers
Yes
Conditions
Interventions
Aspirin 81Mg Ec Tab
81 mg enteric coated aspirin, taken daily from before 14 weeks of gestational age through pregnancy
Aspirin 162Mg Ec Tab
162 mg enteric coated aspirin, taken daily from before 14 weeks of gestational age through pregnancy
Locations (1)
University of Virginia
Charlottesville, Virginia, United States