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Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population
Sponsor: Hospital Alemão Oswaldo Cruz
Summary
The main objective of this project is to evaluate the genomic information previously associated with cardiovascular diseases (CVD) and its importance as an independent risk predictor (expressed in Odds Ratio) when adjusted for traditional risk factors (smoking, diabetes, arterial hypertension, obesity , anxiety and depression, inadequate diet, physical inactivity, alcohol consumption and apolipoprotein B/A1 ratio (ApoB/ApoA1). An unpaired case-control study of individuals over 18 years of age will be carried out. Cases (N = 1867) will be enrolled right after the occurrence of the first atherosclerotic cardiovascular event (Acute Myocardial Infarction, Stroke and Peripheral Artery Thrombotic-Ischemic Events). The ratio between cases and controls will be 1:1. The controls (N = 1867) will be adult individuals over 18 years of age who sought medical care at the same locations for other clinical reasons (no CVD) or individuals without any overt disease. The genetic evaluation will be performed through the association of Low-covering Whole Genome Sequencing (coverage 0.5-5x) and Whole Exome Sequencing (average coverage 30x).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
3974
Start Date
2022-07-18
Completion Date
2024-07-15
Last Updated
2024-05-30
Healthy Volunteers
Yes
Conditions
Interventions
Exposure to genetics (polygenic)
The polygenic risk score (PRS) aggregates the effects of genetic variants into a single number that predicts the genetic predisposition to a phenotype. PRS are typically composed of hundreds to millions of genetic variants, usually Single Nucleotide Polymorphisms (SNPs). For each individual, the number of risk alleles computed in each variant is summed and weighted by the estimated value of the obtained effects (log odds ratio for traits with binary values or Beta coefficients for traits with continuous value) obtained from large-scale genomic studies ( GWAS)
Locations (41)
Acurácia Serviços Médicos
Rio Branco, Acre, Brazil
Centro de Pesquisas Clínicas Dr. Marco Mota HCOR
Maceió, Alagoas, Brazil
Centro de Pesquisa Clínica do Coração
Aracaju, Ceará, Brazil
Hospital Maternidade São Vicente de Paulo
Barbalha, Ceará, Brazil
Hospital Evangélico de Vila Velha
Vila Velha, Espírito Santo, Brazil
Hospital Universitário Cassiano Antônio de Moraes
Vitória, Espírito Santo, Brazil
Hospital e Clínica São Roque
Ipiaú, Estado de Bahia, Brazil
Instituto Cárdio Pulmonar da Bahia
Salvador, Estado de Bahia, Brazil
Universidade Federal de Goiás - UFG
Goiânia, Goiás, Brazil
Hospital Universitário da Universidade Federal do Maranhão/HU/UFMA
São Luís, Maranhão, Brazil
Hospital Universitário Maria Aparecida Pedrossian
Campo Grande, Mato Grosso do Sul, Brazil
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, Minas Gerais, Brazil
Santa Casa de Misericórdia de Belo Horizonte
Belo Horizonte, Minas Gerais, Brazil
Hospital de Clínicas da Universidade Federal do Triângulo Mineiro
Uberaba, Minas Gerais, Brazil
Hospital Geral Filantrópico Universitário - Assoc. de Proteção à Maternidade e Infância de Cuiabá
Cuiabá, Mount, Brazil
Hospital e Maternidade Angelina Caron
Campina Grande do Sul, Paraná, Brazil
Núcleo de Pesquisa Clínica S/S
Curitiba, Paraná, Brazil
Real Hospital Português de Beneficência em Pernambuco
Recife, Pernambuco, Brazil
Hospital Universitário da Universidade Federal do Piauí
Teresina, Piauí, Brazil
Instituto Atena de Pesquisa Clínica
Natal, Rio Grande do Norte, Brazil
Associação Dr. Bartholomeu Tacchini
Bento Gonçalves, Rio Grande do Sul, Brazil
Associacao Hospitalar Beneficente Sao Vicente de Paulo
Passo Fundo, Rio Grande do Sul, Brazil
Santa Casa de Misericórdia de Pelotas
Pelotas, Rio Grande do Sul, Brazil
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Hospital Nossa Senhora Da Conceicao Sa
Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Cardiologia do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, Brazil
Hospital Universitário de Santa Maria
Santa Maria, Rio Grande do Sul, Brazil
Maestri e Kormann Consultoria Medico Cientifica
Blumenau, Santa Catarina, Brazil
H&W Cardiologia LTDA
Joinville, Santa Catarina, Brazil
Hospital Cirurgia
Aracaju, Sergipe, Brazil
Hospital Municipal de Barueri
Barueri, São Paulo, Brazil
Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, Brazil
Scentryfar Pesquisa Clínica
Campinas, São Paulo, Brazil
Hospital Carlos Fenando Malzoni
Matão, São Paulo, Brazil
Braile Hospital Dia Ltda
São José do Rio Preto, São Paulo, Brazil
Fundação Faculdade de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil
Hospital Alemão Oswaldo Cruz
São Paulo, São Paulo, Brazil
Instituto Dante Pazzanese de Cardiologia
São Paulo, São Paulo, Brazil
Instituto de Cardiologia HCFMUSP
São Paulo, São Paulo, Brazil
Instituto de Pesquisa GNDI
São Paulo, São Paulo, Brazil
Hospital Santa Paula
São Paulo, Brazil