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A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis
Sponsor: Mayo Clinic
Summary
The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease.
Official title: Exploratory Study of the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-03-03
Completion Date
2026-12
Last Updated
2026-01-08
Healthy Volunteers
Yes
Conditions
Interventions
Omeprazole
40 MG oral capsules daily
Lactobacillus rhamnosus GG
Given as Culturelle Digestive Probiotic in the form of oral capsules daily
Placebo
Oral capsules daily that look exactly like the study drug, but contains to active ingredient
Locations (1)
Mayo Clinic Arizona
Scottsdale, Arizona, United States