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RECRUITING
NCT05517928
NA

A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

Sponsor: Mayo Clinic

View on ClinicalTrials.gov

Summary

The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease.

Official title: Exploratory Study of the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2023-03-03

Completion Date

2026-12

Last Updated

2026-01-08

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Omeprazole

40 MG oral capsules daily

DIETARY_SUPPLEMENT

Lactobacillus rhamnosus GG

Given as Culturelle Digestive Probiotic in the form of oral capsules daily

DRUG

Placebo

Oral capsules daily that look exactly like the study drug, but contains to active ingredient

Locations (1)

Mayo Clinic Arizona

Scottsdale, Arizona, United States