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Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With History of Inadequate Response to Oral Preventive Medications
Sponsor: Pfizer
Summary
This study is being conducted to evaluate the efficacy and tolerability of rimegepant for migraine prophylaxis in adults with a history of inadequate response to oral preventive medications
Official title: A Phase 4, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With a History of Inadequate Response to Oral Preventive Medications
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
962
Start Date
2022-11-07
Completion Date
2025-07-08
Last Updated
2026-05-22
Healthy Volunteers
No
Conditions
Interventions
Rimegepant
Rimegepant 75 mg Oral Disintegrating Tablet (ODT) taken every other day during Double-blind Treatment (DBT) phase
Placebo
Matching placebo with every other day dosing during DBT phase
Locations (111)
Clinical Research Institute
Los Angeles, California, United States
California Neuroscience Research, LLC
Sherman Oaks, California, United States
Ki Health Partners LLC, dba New England Institute for Clinical Research
Stamford, Connecticut, United States
Sandhill Research, LLC d/b/a Accel Research Sites Network-Edgewater Clinical Research Unit
Edgewater, Florida, United States
Wr-Msra,Llc
Lake City, Florida, United States
AppleMed Research Group, LLC
Miami, Florida, United States
Sensible Healthcare LLC
Ocoee, Florida, United States
Sandhill Research, LLC d/b/a Accel Research Sites Network - Ormond Clinical Research Unit
Ormond Beach, Florida, United States
Boston Clinical Trials
Boston, Massachusetts, United States
Community Clinical Research Network, Inc.
Marlborough, Massachusetts, United States
Michigan Headache & Neurological Institute
Ann Arbor, Michigan, United States
Rochester Medical Group
Rochester Hills, Michigan, United States
Clinvest Research, LLC
Springfield, Missouri, United States
St Charles Clinical Research
Weldon Spring, Missouri, United States
Wr-Crcn, Llc
Las Vegas, Nevada, United States
Albuquerque Clinical Trials. Inc.
Albuquerque, New Mexico, United States
DiGiovanna Institute for Medical Education And Research
North Massapequa, New York, United States
Headache Wellness Center, PC
Greensboro, North Carolina, United States
Synexus Clinical Research US, Inc. - Anderson
Anderson, South Carolina, United States
Alliance for Multispecialty Reseach, LLC
Knoxville, Tennessee, United States
Red Star Research, LLC
Lake Jackson, Texas, United States
DM Clinical Research
Tomball, Texas, United States
Northwest Clinical Research Center
Bellevue, Washington, United States
USC Clinical Trials Sunshine Coast
Sippy Downs, Queensland, Australia
Medical University Innsbruck
Innsbruck, Tyrol, Austria
Klinikum Klagenfurt am Wörthersee
Klagenfurt, Austria
UZ Brussel
Jette, Brussels Capital, Belgium
GZA Ziekenhuizen
Antwerp, Belgium
AZ Sint-Jan Brugge-Oostende AV
Bruges, Belgium
Jessa Ziekenhuis
Hasselt, Belgium
Clinique de la Citadelle
Liège, Belgium
Cabinet Privé Dr. Simona Sava
Saint Nicolas Province de Liège, Belgium
Aggarwal and Associates Limited
Brampton, Ontario, Canada
NeuPath Centre for Pain and Spine
Brampton, Ontario, Canada
Centre de Recherche Saint-Louis/Clinique Neuro-Levis
Lévis, Quebec, Canada
ALPHA Recherche Clinique
Québec, Quebec, Canada
ALPHA Recherche Clinique
Québec, Canada
Bispebjerg Hospital
Copenhagen NV, Capital Region, Denmark
Danish Headache Center
Glostrup Municipality, Capital Region, Denmark
University Hospital of Southern Denmark
Esbjerg, Denmark
Hospitalsenhed Midt
Viborg, Denmark
Terveystalo Ruoholahti
Helsinki, Uusimaa, Finland
Terveystalo Tampere
Tampere, Finland
Terveystalo Pulssi
Turku, Finland
Schmerz- und Palliativzentrum Göppingen
Göppingen, Baden-Wurttemberg, Germany
Zentrum für klinische Forschung
Bad Homburg, Hesse, Germany
Synexus Clinical Research GmbH Synexus Frankfurt Clinical Research Centre
Frankfurt am Main, Hesse, Germany
Kopfschmerzzentrum Frankfurt
Frankfurt am Main, Hesse, Germany
Intermed GmbH
Wiesbaden, Hesse, Germany
Studienzentrum Nordwest
Westerstede, Lower Saxony, Germany
Synexus - Prüfzentrum Leipzig
Leipzig, Saxony, Germany
Synexus - Prüfzentrum Berlin
Berlin, Germany
Neuropoint GmbH
Ulm Baden-Wuerttemberg, Germany
IRCCS Fondazione Istituto Neurologico Nazionale C. Mondino
Pavia, Lombardy, Italy
IRCCS Ospedale San Raffaele
Milan, MI, Italy
AOU Luigi Vanvitelli
Naples, Naples, Italy
IRCCS San Raffaele
Rome, Rome/lazio, Italy
SOD Centro Cefalee e Farmacologia Clinica, AOU Careggi
Florence, Italy
IRCCS Fondazione Besta
Milan, Italy
University Modena e Reggio Emilia
Modena, Italy
Phylasis Clinicas Research S. de R.L. de C.V.
Cuautitlán Izcalli, State of Mexico, Mexico
Clinical Research Institute S.C.
Tlalnepantla, State of Mexico, Mexico
Medical Care and Research S.A. de C.V.
Mérida, Yucatán, Mexico
Centro de Investigación Médica de Aguascalientes (CIMA)
Aguascalientes, Mexico
Clinstile, SA de CV
Mexico City, Mexico
Operadora Unidad de Investigación En Salud de Chihuahua, Sa de Cv
Mexico City, Mexico
Centrum Medyczne Neuromed
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak
Wroclaw, Lower Silesian Voivodeship, Poland
Twoja Przychodnia Nowosolskie Centrum Medyczne
Nowa Sól, Lubusz Voivodeship, Poland
Centermed Kraków Sp. Z o.o.
Krakow, Malopolska, Poland
Concept Medica
Warsaw, Masovian Voivodeship, Poland
Dr Sekowska Leczenie Bolu
Warsaw, Masovian Voivodeship, Poland
MICS Centrum Medyczne Damiana Walbrzyska
Warsaw, Masovian Voivodeship, Poland
Instytut Zdrowia
Oświęcim, Małopolska, Poland
Centrum Medyczne Pratia Katowice
Katowice, Poland
Vita Longa Sp. Z o.o.
Katowice, Poland
MICS Centrum Medyczne Szczecin
Szczecin, Poland
MTZ Clinical Research Powered by Pratia
Warsaw, Poland
Premium Clinic Wrocław
Wroclaw, Poland
Centrum Medyczne OPOROW
Wroclaw, Poland
Centrum Leczenia Bolu dr n med Lukasz Kmieciak
Lodz, Łódź Voivodeship, Poland
Hospital Universitario de Elda
Elda, Alicante, Spain
Hospital Clinic de Barcelona Plato Headquarters
Barcelona, Spain
Hospital Universitario Vall d'Hebron
Barcelona, Spain
Hospital Universitario de La Princesa
Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario HM Sanchinarro
Madrid, Spain
Hospital Universitario Ruber Juan Bravo
Salamanca, Spain
University Hospital Marqués de Valdecilla
Santander, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Virgen del Rocio University Hospital
Seville, Spain
Hospital Clínico Universitario de Valencia
Valencia, Spain
Consorcio Hospital General Universitario
Valencia, Spain
Hospital Clinico Universitario de Valladolid
Valladolid, Spain
CTC Solna
Solna, Stockholms LÄN [se-01], Sweden
CTC MTC
Uppsala, Uppsala LÄN [se-03], Sweden
Carlanderska Hospital
Gothenburg, Sweden
Skåneuro Privatmottagning
Lund, Sweden
Hälsoklustret
Stockholm, Sweden