Clinical Research Directory

Inclusion Criteria: * Signing of an informed consent form (ICF) before randomization and any study procedure, * Both genders, age \>18 years and \<75 years, * Recent positive (last two years) and documented serology for Chagas disease, in at least two different tests (indirect hemagglutination, indirect immunofluorescence, or ELISA), * NYHA II-III heart failure functional class, * LVEF\< 35%, * Non left bundle branch block * Intraventricular desynchrony (Yu index) * Global longitudinal strain \>11 %. Exclusion Criteria: * Participation in another study, presently or terminated \<1 year ago, except for a totally unrelated observational study, * Other concomitant cardiovascular diseases, including uncontrolled diabetes mellitus (systemic arterial hypertension without permitted target organ compromise), * Kidney dysfunction (serum creatinine \>1.5mg/dL or eGFR \<30mL/min/1.73m2) or liver dysfunction, with diagnosis of cirrhosis or portal hypertension or elevated serum enzymes (AST or ALT) \> 3x the upper limit of normality, * Moderate or severe chronic obstructive pulmonary disease, * Peripheral polyneuropathy, * Hyperthyroidism, * Current alcoholism or not abandoned for \>2 years, * Diagnosed with psychopathy or psychosis or addiction to illicit drugs, * Life expectancy \<1 year, due to the disease itself or comorbidities (including NYHA class IV), * Pregnancy or breastfeeding, * Potential to become pregnant during the study (non-menopausal patients who have not undergone a radical and safe contraceptive process), * Previously withdrawn from this study.