Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have metabolic dysfunction-associated steatohepatitis (MASH). MASH is a form of metabolic dysfunction-associated steatotic liver disease (MASLD). MASH occurs when fat builds up in liver cells, damaging them, and making the liver inflamed and stiff from fibrosis (scar tissue). MASH can progress to cirrhosis (long term scarring) and liver failure (when the liver cannot perform its job). The aim of the study is to see the effect of the study drug on lessening liver scarring side effects related to MASH. The study is looking at several other research questions, including: * How ALN-HSD works to improve liver function and lessen MASH-related inflammation in the liver * What side effects may happen from receiving the study drug * How much study drug and study drug metabolites (byproduct of the body breaking down the study drug) are in the blood at different times * Better understanding of the study drug and MASH
Official title: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of siRNA Gene Silencing for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Participants With Genetic Risk Factors
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2023-02-09
Completion Date
2027-09-08
Last Updated
2026-02-03
Healthy Volunteers
No
Interventions
ALN-HSD
Administered by subcutaneous injection (SC)
Placebo
Administered by SC injection
Locations (71)
Arizona Liver Health
Chandler, Arizona, United States
The Institute for Liver Health II LLC DBA Arizona Clinical Trials - Flagstaff
Flagstaff, Arizona, United States
The Institute for Liver Health II LLC DBA Arizona Liver Health - Peoria
Peoria, Arizona, United States
Adobe Clinical Research
Tucson, Arizona, United States
Arizona Liver Health - Tucson
Tucson, Arizona, United States
Del Sol Research Management, LLC
Tucson, Arizona, United States
San Fernando Valley Health Institute
Canoga Park, California, United States
Velocity Clinical Research
Chula Vista, California, United States
Southern California Research Center
Coronado, California, United States
Ark Clinical Research - Fountain Valley
Fountain Valley, California, United States
Velocity Clinical Research
Gardena, California, United States
Velocity Clinical Research - Huntington Park
Huntington Park, California, United States
Om Research Llc
Lancaster, California, United States
Ark Clinical Research - Long Beach
Long Beach, California, United States
Velocity Clinical Research - Westlake
Los Angeles, California, United States
Clinnova Research Solutions
Orange, California, United States
Knowledge Research Center, St. Joseph's Medical Tower
Orange, California, United States
National Research Institute
Panorama City, California, United States
California Liver Research Institute
Pasadena, California, United States
Cadena Care Inst.
Poway, California, United States
Inland Empire Liver Foundation
Rialto, California, United States
Precision Research Institute - San Diego
San Diego, California, United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Synergy Healthcare LLC
Bradenton, Florida, United States
Evolution Clinical Trials
Hialeah Gardens, Florida, United States
Health Awareness, inc.
Jupiter, Florida, United States
Miami Clinical Research
Miami, Florida, United States
International Medical Investigational Centers (IMIC) Incorporated
Miami, Florida, United States
Genoma Research Group, Inc.
Miami, Florida, United States
US Associates in Research, LLC
Miami, Florida, United States
Med Research of Florida, LLC
Miami, Florida, United States
Charter Research LLC - Orlando
Orlando, Florida, United States
Indiana University School of Medicine
Indianapolis, Indiana, United States
Deaconess Clinic - GI Specialty Center
Newburgh, Indiana, United States
Tandem Clinical Research
Metairie, Louisiana, United States
Mercy Medical Center
Baltimore, Maryland, United States
GI Associates
Flowood, Mississippi, United States
Washington University School of Medicine
St Louis, Missouri, United States
Columbia University Irving Medical Center
New York, New York, United States
Geisinger Medical Center
Danville, Pennsylvania, United States
Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
University of Pennsylvania - Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, United States
Austin Clinical Research, LLC
Austin, Texas, United States
American Research Corporation
Austin, Texas, United States
Pinnacle Clinical Research - Austin
Austin, Texas, United States
South Texas Research Institute (STRI) - Brownsville
Brownsville, Texas, United States
Velocity Clinical Research - Austin
Cedar Park, Texas, United States
Methodist Dallas Medical Center
Dallas, Texas, United States
South Texas Research Institute (STRI) - Edinburg
Edinburg, Texas, United States
GI Alliance Research
Fort Worth, Texas, United States
Allure Health at Mt. Olympus Medical Research
Friendswood, Texas, United States
Advanced Medical Trials
Georgetown, Texas, United States
Pioneer Research Solutions, Inc.
Houston, Texas, United States
R & H Clinical Research, Inc.
Katy, Texas, United States
Great Lakes Research Institute
Pharr, Texas, United States
American Research Corporation at The Texas Liver Institute
San Antonio, Texas, United States
Pinnacle Clinical Research - San Antonio
San Antonio, Texas, United States
R & H Clinical Research
Stafford, Texas, United States
Intermountain Health
Murray, Utah, United States
University of Virginia Medical Center
Charlottesville, Virginia, United States
Richmond Veterans Administration Medical Center
Richmond, Virginia, United States
JCHO Hokkaido Hospital
Sapporo, Hokkaido, Japan
Isis Clinical Research Center
Guaynabo, San Juan, Puerto Rico
Klinical Investigations
San Juan, Puerto Rico
Latin Clinical Trial Center
San Juan, Puerto Rico
Fundacion de Investigacion (FDI) Clinical Research
San Juan, Puerto Rico
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Pusan National University Hospital
Busan, South Korea
Kyungpook National University Hospital
Daegu, South Korea
Keimyung University Dongsan Hospital
Daegu, South Korea
Hanyang University Seoul Hospital
Seoul, South Korea