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Evaluating the Effects of Cannabis Use and Circulating Cannabinoids on Tumor Infiltrating Lymphocytes in Malignant Melanoma
Sponsor: University of Colorado, Denver
Summary
The goal of this proposal is to determine how cannabinoid use affects the tumor immune microenvironment (TME) of melanoma by correlating TILs with reported cannabinoid use and circulating plasma cannabinoids. The central hypothesis is that cannabinoid use decreases TILs in melanoma in a dose-dependent fashion. This is important because cannabinoid-driven TME changes in melanoma may alter patient outcomes mediated by TILs and response to standard of care ICI treatments.
Key Details
Gender
All
Age Range
21 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
90
Start Date
2022-09-01
Completion Date
2024-08-31
Last Updated
2024-04-17
Healthy Volunteers
Not specified
Conditions
Interventions
High-performance liquid chromatography-tandem mass spectrometry assays
Paraffin blocks will be requested for slide creation, and at least 12 mL of whole blood will be collected in 2 green top tubes, centrifuged, and plasma transferred for storage at -80 C until further processing
Locations (1)
University of Colorado Denver
Aurora, Colorado, United States