Clinical Research Directory

Inclusion Criteria: 1. An Institutional Review Board (IRB) approved informed consent is signed and dated before any study-related activities. 2. Male and female subjects ages 18 to 75, inclusive. 3. Documented history of at least two (2) seizures per week. Seizures can be generalized and/or focal. 4. Diagnosed with intractable or refractory epilepsy. 5. Have a caregiver/family member who stays with the subject, has the ability to detect seizures, and is willing to provide the information needed for the study. 6. Have implanted vagus nerve stimulation (VNS). 7. Have the ability to understand the requirements of the study and are willing to comply with all study requirements. 8. Must have a working Apple iPhone. Exclusion Criteria: 1. Women who are either pregnant or breastfeeding. 2. Subjects unable/unwilling to wear the Apple Watch and EEG Wearable for extended periods. 3. Requires the use of a ventilator. 4. Requires the use of supplemental oxygen. 5. Uses a pacemaker or other electronic neurostimulator, except the VNS. 6. Any medical or surgical condition that in the opinion of the investigator may interfere with participation in the study.