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Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The purpose of this study is to determine whether first-trimester screening for preeclampsia based on the FMF algorithm (a combination of maternal clinical, sonographic and biochemical parameters), improves maternal or perinatal health.
Official title: Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity : a Multicenter Randomized Trial
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
14500
Start Date
2023-03-06
Completion Date
2027-02
Last Updated
2026-03-27
Healthy Volunteers
No
Conditions
Interventions
First-trimester preeclampsia screening (FMF triple test)
An algorithm assessing the risk of developing preeclampsia combining maternal parameters, blood pressure measurement, Doppler measurements of the uterine arteries and maternal PlGF concentrations. For women in the screening group, a Doppler study of the uterine arteries and a blood test to quantify PlGF concentrations will be performed within 2 days of randomization, allowing the risk to be calculated according to the screening test. For women with a positive screening test (i.e. predicted risk\> 1/100), a treatment with aspirin will be prescribed at 160 mg/day, started as soon as possible and before 15 WG, and taken up to 36 WG, in the absence of contraindications. For women with negative screening, usual pregnancy monitoring without aspirin will be offered.
Locations (22)
CHU Angers
Angers, France
CHU de Bordeaux
Bordeaux, France
Hôpital Femme Mère Enfant
Bron, France
Hôpital Antoine Béclère
Clamart, France
CHU Estaing
Clermont-Ferrand, France
Hôpital Intercommunal Créteil
Créteil, France
CHU Dijon Bourgogne
Dijon, France
CHU Lille
Lille, France
Hôpital de la conception et de la Timone
Marseille, France
Hôpital Nord
Marseille, France
CHRU de Nancy
Nancy, France
Hôpital Femme - Maternité
Nantes, France
Hôpital Armand Trousseau
Paris, France
Hôpital Cochin (site Port-Royal)
Paris, France
Hôpital Saint-Joseph
Paris, France
CHI de Poissy
Poissy, France
Hôpital Sud Rennes
Rennes, France
CHU Charles Nicolle
Rouen, France
CHU Strasbourg, CMCO Schiltigheim
Strasbourg, France
Hôpital de Hautepierre
Strasbourg, France
Hôpital Paule de Viguier
Toulouse, France
Hôpital Bretonneau
Tours, France