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Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
Sponsor: University of Utah
Summary
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower extremity fractures who do not develop compartment syndrome.
Official title: Genetics and Local Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2022-06-10
Completion Date
2028-06
Last Updated
2025-08-12
Healthy Volunteers
No
Interventions
Acute injury without compartment syndrome
Acute tibial shaft or tibial plateau fractures who do not have clinical compartment syndrome. Muscle punch biopsy of the anterior compartment will be taken.
Acute injury with compartment syndrome
Acute tibial shaft or tibial plateau fractures who have clinical compartment syndrome. Muscle punch biopsy of the anterior compartment will be taken.
Exertional compartment syndrome
For patients with exertional compartment syndrome, a muscle biopsy will be obtained from affected extremity.
Locations (1)
University of Utah Orthopaedic Center
Salt Lake City, Utah, United States