Clinical Research Directory

Inclusion Criteria: * gout flare:diagnosis with gout flare at this hospital according to the criteria approved by the ACR Board of Directors and the EULAR Executive Committee in 2015 * intercritical gout: remission of gout patients were classified into intercritical gout group without tophi, chronic gouty arthritis, or imaging erosion(All of these gout remission patients underwent dual-energy CT test within one month, and were detected to have MSU crystal deposition in local joints) * advanced gout: gout remission patients were classified into advanced gout group characterized by tophi, chronic gouty arthritis, or imaging erosion(All of these gout remission patients underwent dual-energy CT test within one month, and were detected to have MSU crystal deposition in local joints) * asymptomatic hyperuricemia: hyperuricemia in men was defined as SUA ≥ 420 mmol/L without any complications Exclusion Criteria: * primary osteoarticular diseases * unwilling participation in the study * corticosteroids or indomethacin use in the past 3 months; * septic arthritis or another joint disease (such as rheumatoid arthritis); * impaired renal function (creatinine clearance \<30 mL/min) and other conditions which may increase the level of blood uric acid